Human Papillomavirus Integration: The Mechanism(s) Behind the High-Risk Associated with this Event and Cervical Disease Progression
نویسندگان
چکیده
High risk Human Papilloma Virus (HR-HPV) DNA integration into the human genome isone of the key stages in the progression of cervical neoplasia. This mini-review highlights theimportance of HPV integration as a potential biomarker for cervical screening and brieflydescribes the main methods used to detect HPV integration: Amplification of PapillomavirusOncogene Transcripts (APOT), Restriction Site PCR (RS-PCR), Southern blot and Detectionof Integrated Papillomavirus Sequences (DIPS). The potential mechanisms of HPVintegration are discussed with a focus on DNA instability; site of integration; andtranscriptional regulation of integrants. This article provides an overview of the role HPVintegration plays in malignant progression.
منابع مشابه
Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16
Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...
متن کاملPrevalence of Human Papillomavirus In Women With Abnormal Pap Smear In Boyer Ahmad City
Abstract Background & aim: Human papillomavirus (HPV) is the most common sexually transmitted disease that is major risk factor for the development of precancerous and cancerous cervical lesions. This study was planned to evaluate the prevalence of HPV and its genotypes in women with abnormal Pap smear who referred to shahid Mofateh clininc. Methods: A total of 67 cervical cytology sample inc...
متن کاملHuman Papillomavirus and Cancer - Immunological Consequences of MHC Class I Down-Regulation
Few studies have been conducted on the causative factors associated with the development of cancer. Infection by high risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers. HPV is capable of evading immune system and establishing persistent infections. Prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...
متن کاملPreventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers
Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based ...
متن کاملStudy of Frequency of High Grade Cervical Intraepithelial Neoplasms (CIN 2, 3) in Patients Infected with Uncommon High Risk Human Papillomavirus
Introduction: Despite the significant relationship between human papillomavirus 16 and 18 subtypes and severe cases of cervical cancer, the assessing the frequency of high-grade cervical intraepithelial neoplasms in the patients infected with high-risk human papillomavirus other than 16 and 18 has been less studied in Iranian population. Methods: In this cross-sectional study, the patients ref...
متن کامل